Rheumatoid Arthritis (RA) is an autoimmune disorder that causes swollen and painful joints, particularly in the hands, feet, wrists and elbows. Other symptoms of RA include inflammation of the lungs and heart, as well as low red blood cell count. The cause of this disorder is not known for certain, but can be a result of differing genetic and environmental factors. RA affects between 0.5 to 1% of adults in the developed world.
Do you suffer from discomfort or pain caused by Rheumatoid Arthritis?
This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe Rheumatoid Arthritis (RA).
Would you like to take part?
As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular study-related follow up on your RA to monitor the effectiveness of the care you’ll receive. The results of this research will be used to determine whether or not the medication being studied will be of benefit to others with early RA. Study volunteers are an important part of moving medical care forward.
You may qualify to participate in this study if you:
- Are age 18 years or older
- Have a diagnosis of Rheumatoid Arthritis based on ACR/EULAR 2010 classification criteria, for at least 3 months before participating in the trial
- Have been receiving treatment with at least 1, but not more than 2 csDMARDs for at least 3 months and be on stable dosages for at least 8 weeks prior to joining and throughout the trial
- Have had an inadequate response to, or loss of response or intolerance to at least 1 conventional synthetic DMARD (csDMARD), biologic DMARD (bDMARD), or targeted synthetic DMARD (tsDMARD) treatment
You may not qualify to participate in this study if you:
- Have a history of an inflammatory joint disease other than Rheumatoid Arthritis
- Have experienced prior exposure to a PD-1 or PD-L1 agonist, antagonist, or modulator
- Have a history of cancer within the last 5 years (except for some skin cancers)
- Have any known or suspected condition that would compromise your immune status
- Are pregnant or breastfeeding
There are other eligibility requirements that the study doctor will review. Only the study doctor can finally determine whether you are eligible to participate in the study or not.