{"id":34175,"date":"2025-02-07T10:37:16","date_gmt":"2025-02-07T15:37:16","guid":{"rendered":"https:\/\/joinastudy.ca\/?p=34175"},"modified":"2025-02-07T10:39:45","modified_gmt":"2025-02-07T15:39:45","slug":"higher-dose-semaglutide-shows-promising-weight-loss-results","status":"publish","type":"post","link":"https:\/\/joinastudy.ca\/fr\/higher-dose-semaglutide-shows-promising-weight-loss-results\/","title":{"rendered":"Novo Nordisk&rsquo;s Higher-Dose Semaglutide Shows Promising Weight Loss Results"},"content":{"rendered":"<p><span data-contrast=\"auto\">Novo Nordisk is exploring a higher-dose version of <\/span><b><span data-contrast=\"auto\">semaglutide<\/span><\/b><span data-contrast=\"auto\"> to enhance weight loss treatments. In a recent phase 3b clinical trial called STEP UP, a 7.2-mg weekly dose of semaglutide helped participants lose an average of 20.7% of their body weight over 72 weeks. This significantly outperformed the 2.4-mg dose marketed as Wegovy, which led to a 17.5% weight loss, and placebo, which achieved just 2.4%.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">JoinAStudy.ca would like to congratulate Principal Investigator\u202f<\/span><a href=\"https:\/\/joinastudy.ca\/study-locations\/london-east-medical-centre-dr-dzongowski\/\"><span data-contrast=\"none\">Dr Peter Dzongowski<\/span><\/a><span data-contrast=\"auto\">\u202fand his team at Milestone Research, whose efforts were crucial in gathering the data necessary to arrive at these conclusions. The study participants at his research site also deserve acknowledgment and thanks for providing their valuable time and effort.\u202f\u202f\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The trial, involving 1,407 participants with an average starting weight of 113 kg (249 pounds), revealed even more impressive outcomes for some patients. Around 33.2% of those on the 7.2-mg dose lost at least 25% of their body weight, compared to 16.7% on the 2.4-mg dose and none on the placebo.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Safety data showed the higher dose was well-tolerated, with mild to moderate gastrointestinal side effects consistent with other GLP-1 receptor agonists. Novo Nordisk plans to present detailed results soon and is conducting another trial, STEP UP T2D, to test the 7.2-mg dose in patients with Type 2 diabetes and obesity.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Despite these promising findings, Novo faces challenges in a highly competitive market. Eli Lilly\u2019s rival drug, Zepbound, recently demonstrated comparable weight loss results in its SURMOUNT-5 trial. Additionally, Novo\u2019s stock price dropped 4%, potentially reflecting investor concerns about Medicare price negotiations and competition.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The results suggest semaglutide 7.2 mg could be a game-changer in obesity treatment. However, Novo\u2019s ability to maintain its market edge against competitors like Eli Lilly remains to be seen.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Novo Nordisk is exploring a higher-dose version of semaglutide to enhance weight loss treatments. In a recent phase 3b clinical trial called STEP UP, a 7.2-mg weekly dose of semaglutide helped participants lose an average of 20.7% of their body weight over 72 weeks. This significantly outperformed the 2.4-mg dose marketed as Wegovy, which led<\/p>\n","protected":false},"author":964,"featured_media":26920,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[603,487,489,513,550],"tags":[],"class_list":["post-34175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-obesity-weight-loss","category-drug-development","category-industry-news","category-health-and-wellness","category-study-results","category-603","category-487","category-489","category-513","category-550","description-off"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Higher-Dose Semaglutide Shows Promising Weight Loss Results<\/title>\n<meta name=\"description\" content=\"Novo Nordisk is exploring a 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