{"id":35081,"date":"2025-06-24T00:27:09","date_gmt":"2025-06-24T04:27:09","guid":{"rendered":"https:\/\/joinastudy.ca\/la-fda-approuve-nucala-pour-les-patients-atteints-de-mpoc-avec-un-taux-eleve-deosinophiles\/"},"modified":"2025-06-24T00:29:31","modified_gmt":"2025-06-24T04:29:31","slug":"la-fda-approuve-nucala-pour-les-patients-atteints-de-mpoc-avec-un-taux-eleve-deosinophiles","status":"publish","type":"post","link":"https:\/\/joinastudy.ca\/fr\/la-fda-approuve-nucala-pour-les-patients-atteints-de-mpoc-avec-un-taux-eleve-deosinophiles\/","title":{"rendered":"La FDA approuve Nucala pour les patients atteints de MPOC avec un taux \u00e9lev\u00e9 d\u2019\u00e9osinophiles"},"content":{"rendered":"

La Food and Drug Administration (FDA) des \u00c9tats-Unis a approuv\u00e9 Nucala (m\u00e9polizumab) comme traitement d\u2019appoint pour les adultes atteints de maladie pulmonaire obstructive chronique (MPOC) qui continuent de pr\u00e9senter des exacerbations malgr\u00e9 une triple th\u00e9rapie inhal\u00e9e. Nucala est le premier m\u00e9dicament biologique sp\u00e9cifiquement approuv\u00e9 pour les patients MPOC pr\u00e9sentant un \u00ab\u202fph\u00e9notype \u00e9osinophilique\u202f\u00bb \u2014 un groupe d\u00e9fini par un taux \u00e9lev\u00e9 d\u2019\u00e9osinophiles, un type de globule blanc associ\u00e9 \u00e0 l\u2019inflammation.<\/strong><\/p>\n

Environ 70\u202f% des patients atteints de MPOC aux \u00c9tats-Unis qui souffrent encore de sympt\u00f4mes malgr\u00e9 le traitement ont un taux sanguin d\u2019\u00e9osinophiles de 150 cellules\/\u03bcL ou plus. Administr\u00e9 par injection mensuelle, Nucala agit en ciblant l\u2019interleukine-5 (IL-5), une prot\u00e9ine impliqu\u00e9e dans l\u2019inflammation. En r\u00e9duisant les \u00e9osinophiles, Nucala contribue \u00e0 diminuer le risque d\u2019exacerbations de la MPOC, y compris celles n\u00e9cessitant une hospitalisation ou une visite \u00e0 l\u2019urgence.<\/p>\n

Cette approbation repose sur des r\u00e9sultats solides issus de deux essais cliniques majeurs, MATINEE et METREX. Dans ces \u00e9tudes, Nucala a r\u00e9duit de mani\u00e8re significative le nombre d\u2019exacerbations mod\u00e9r\u00e9es \u00e0 s\u00e9v\u00e8res par rapport au placebo. Dans l\u2019un des essais, une baisse du taux de visites \u00e0 l\u2019h\u00f4pital a \u00e9galement \u00e9t\u00e9 observ\u00e9e, bien que ce r\u00e9sultat n\u2019ait pas \u00e9t\u00e9 statistiquement significatif.<\/p>\n

JoinAStudy.ca tient \u00e0 f\u00e9liciter le chercheur principal, le Dr Syed Anees<\/a>, dont les efforts ont \u00e9t\u00e9 essentiels pour recueillir les donn\u00e9es ayant permis d\u2019atteindre ces conclusions. Les participants \u00e0 l\u2019\u00e9tude ainsi que l\u2019\u00e9quipe de coordination sur son site de recherche m\u00e9ritent \u00e9galement d\u2019\u00eatre remerci\u00e9s pour le temps et l\u2019engagement qu\u2019ils ont consacr\u00e9s.<\/p>\n

La MPOC est une maladie pulmonaire progressive qui touche plus de 390\u202fmillions de personnes dans le monde et repr\u00e9sente la troisi\u00e8me cause de d\u00e9c\u00e8s. Les sympt\u00f4mes incluent l\u2019essoufflement, la toux et la production de mucus. Bien que les th\u00e9rapies inhal\u00e9es soulagent de nombreux patients, une grande proportion continue de subir des exacerbations graves. Nucala offre une nouvelle option pour ces personnes.<\/p>\n

GSK, le fabricant de Nucala, poursuit \u00e9galement le processus d\u2019approbation pour cette utilisation dans d\u2019autres pays.<\/p>\n

Vous pouvez en lire davantage sur ce sujet en cliquant ici.<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

La Food and Drug Administration (FDA) des \u00c9tats-Unis a approuv\u00e9 Nucala (m\u00e9polizumab) comme traitement d\u2019appoint pour les adultes atteints de maladie pulmonaire obstructive chronique (MPOC) qui continuent de pr\u00e9senter des exacerbations malgr\u00e9 une triple th\u00e9rapie inhal\u00e9e. Nucala est le premier m\u00e9dicament biologique sp\u00e9cifiquement approuv\u00e9 pour les patients MPOC pr\u00e9sentant un \u00ab\u202fph\u00e9notype \u00e9osinophilique\u202f\u00bb \u2014 un groupe<\/p>\n","protected":false},"author":964,"featured_media":34819,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[775,776,777,772,773,774],"tags":[],"class_list":["post-35081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-de-lindustrie","category-resultats-detude","category-mpoc","category-sante-et-bien-etre","category-developpement-de-medicaments","category-sante-canada-et-la-fda","category-775","category-776","category-777","category-772","category-773","category-774","description-off"],"acf":[],"yoast_head":"\nLa FDA approuve Nucala pour les patients atteints de MPOC<\/title>\n<meta name=\"description\" content=\"Nucala est 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