{"id":35570,"date":"2025-11-04T17:21:32","date_gmt":"2025-11-04T22:21:32","guid":{"rendered":"https:\/\/joinastudy.ca\/?p=35570"},"modified":"2025-12-09T11:59:26","modified_gmt":"2025-12-09T16:59:26","slug":"glp-1-agonists-what-they-are-what-makes-them-unique","status":"publish","type":"post","link":"https:\/\/joinastudy.ca\/fr\/glp-1-agonists-what-they-are-what-makes-them-unique\/","title":{"rendered":"GLP-1 Agonists: What They Are & What Makes Them Unique"},"content":{"rendered":"

Curious about the science behind today\u2019s most talked-about diabetes and weight-management treatments? Our new, four-part blog series on GLP-1 Agonists<\/strong> will break down everything you need to know \u2014 from how these drugs work, to their real-world results, side effects, and what\u2019s coming next in the pipeline.<\/p>\n

GLP-1<\/strong> stands for glucagon-like peptide-1<\/a><\/i>. It\u2019s an incretin hormone produced in the gut that stimulates insulin secretion (when glucose is high), suppresses glucagon, slows gastric emptying and increases the feeling of fullness.<\/p>\n

GLP-1 receptor agonists (GLP-1 RAs) are drugs that mimic or augment the effect of GLP-1. They are used mainly in patients with type 2 diabetes mellitus (T2DM)<\/a><\/b> for improving glycemic control, and many are also approved (or used off-label) for weight management \/ obesity<\/a><\/b>.<\/p>\n

They generally have a low risk of causing hypoglycemia when used alone (because their insulin-stimulating effect depends on blood glucose). They can also help reduce appetite and lead to weight loss.<\/p>\n

 <\/p>\n

Currently Available and Approved GLP-1s<\/b><\/p>\n

The table below shows a summary of GLP-1 receptor agonists approved by U.S. and Canadian federal health authorities as of mid-2025, the primary indication they are used for, and key differentiators between them:<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Drug (brand-name \/ generic)<\/b><\/td>\nManufacturer(s)<\/b><\/td>\nFrequency \/ Route<\/b><\/td>\nApproved Indications*<\/b><\/td>\nKey Notes \/ Advantages & Limitations<\/b><\/td>\n<\/tr>\n
Semaglutide<\/b> \u2014 Ozempic\u00ae<\/a><\/i> (injection)<\/td>\nNovo Nordisk<\/a><\/td>\nOnce weekly subcutaneous injection<\/td>\nT2DM; also cardiovascular risk reduction<\/b> in T2DM in certain patients with cardiovascular disease (CVD).<\/td>\nVery effective at lowering HbA1c; good for weight loss though full obesity dose = different brand (see Wegovy). Some GI side effects.<\/td>\n<\/tr>\n
Semaglutide<\/b> \u2014 Wegovy\u00ae<\/a><\/i> (higher dose injection)<\/td>\nNovo Nordisk<\/a><\/td>\nOnce weekly SC injection<\/td>\nFor weight management \/ obesity<\/b> (in adults and adolescents 12+ in many regions) with or without T2DM.<\/td>\nThe obesity-approved dose is higher than the dose in diabetes treatment. Tend to get more weight loss. More cost and possibly more side effects.<\/td>\n<\/tr>\n
Semaglutide<\/b> \u2014 Rybelsus\u00ae<\/a><\/i> (oral)<\/td>\nNovo Nordisk<\/a><\/td>\nDaily oral tablet<\/td>\nT2DM only (for glycemic control)<\/td>\nOral option is helpful for those who dislike or cannot use injections. Bioavailability is lower; may need specific administration instructions (e.g., empty stomach, water only, waiting before food) to maximize absorption. Side effects typically similar GI types.<\/td>\n<\/tr>\n
Liraglutide<\/b> \u2014 Victoza\u00ae<\/a><\/i><\/td>\nNovo Nordisk<\/a><\/td>\nDaily injection<\/td>\nT2DM; also reduces cardiovascular events in some patients.<\/td>\nHas been around longer, good track record. Dose is daily rather than weekly, which some may find less convenient.<\/td>\n<\/tr>\n
Liraglutide<\/b> \u2014 Saxenda\u00ae<\/a><\/i><\/td>\nSame (higher dose)<\/td>\nDaily injection<\/td>\nFor obesity \/ weight management (adults (and adolescents depending on region) meeting obesity or overweight + comorbidity criteria)<\/td>\nThe obesity dose is higher; side effects generally similar (GI, etc.). Requires daily administration.<\/td>\n<\/tr>\n
Dulaglutide<\/b> \u2014 Trulicity\u00ae<\/a><\/i><\/td>\nEli Lilly<\/a><\/td>\nOnce weekly injection<\/td>\nT2DM; also has cardiovascular risk-reduction evidence in T2DM with risk factors.<\/td>\nWeekly dosing is convenient. Less heavy data for obesity (versus some others) though weight loss is a side effect.<\/td>\n<\/tr>\n
Exenatide<\/b> \u2014 Byetta\u00ae<\/a><\/i> (twice daily) & Bydureon\u00ae \/ Bydureon BCise<\/a><\/i> (extended-release weekly)<\/td>\nAstraZeneca<\/a><\/td>\nTwice daily for Byetta; once weekly for Bydureon ER\/BCise<\/td>\nT2DM glycemic control<\/td>\nThe twice daily version has more GI side effects and requires more frequent dosing; extended release is more convenient. Less potent in weight loss than some newer agents. Note: some formulations may not be marketed in all countries.<\/td>\n<\/tr>\n
Lixisenatide<\/b> \u2014 Adlyxin\u00ae<\/a><\/i> (U.S.) \/ Adlyxine<\/i> (other regions)<\/td>\nSanofi<\/a><\/td>\nDaily injection<\/td>\nT2DM glycemic control<\/td>\nShort-acting; useful in certain situations like postprandial glucose spikes; fewer data for weight loss vs others.<\/td>\n<\/tr>\n
Tirzepatide<\/b> \u2014 Mounjaro\u00ae<\/a><\/i> (for diabetes) \/ Zepbound\u00ae<\/a><\/i> (for weight)<\/td>\nEli Lilly<\/a><\/td>\nOnce weekly injection<\/td>\nDual GLP-1 \/ GIP receptor agonist. Approved for T2DM (Mounjaro) and obesity (Zepbound) in adults.<\/td>\nAmong the most potent for weight loss. Dual-mechanism may offer advantages in efficacy. Side effects tend to be more pronounced especially GI; cost is higher; long-term safety still being accumulated.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

In Part 2<\/strong>, we evaluate how to choose between GLP-1 molecules, using a goal-based approach. It’s releasing exclusively on our blog November 6th, so make sure to add us to your bookmarks to stay up to date!:
\nhttps:\/\/joinastudy.ca\/canadian-health-blog\/<\/a><\/p>\n

 <\/p>\n

 <\/p>\n

Sources<\/span><\/b>\u00a0<\/span><\/p>\n

https:\/\/my.clevelandclinic.org\/health\/treatments\/13901-glp-1-agonists<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/medeffect-canada\/health-product-infowatch\/december-2024.html<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/26371721\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.endocrinologyadvisor.com\/ddi\/glp-1-agonists\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/hopkinsdiabetesinfo.org\/medications-for-type-2-diabetes-glp-1-agonists\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551568\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.ncbi.nlm.nih.gov\/books\/n\/rc72848269830370\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/drug-products\/drug-shortages\/information-consumers\/supply-notices\/ozempic.html<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.practicenursing.com\/content\/clinical\/glp-1-receptor-agonists-and-their-role-in-managing-type-2-diabetes<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.drugs.com\/medical-answers\/glp-1-drug-best-weight-loss-3579236\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.primetherapeutics.com\/en\/glp-1-pipeline-update-november-2024<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/drug-products\/drug-shortages\/information-consumers\/supply-notices\/ozempic.html\/1000.html<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.avalanchept.com\/post\/comprehensive-list-of-fda-approved-glp-1-receptor-agonists-as-of-mid-2025<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.powerpak.com\/course\/content\/118150<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.powerpak.com\/course\/content\/114864<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.primetherapeutics.com\/glp-1-pipeline-update-february-2025<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/primetherapeutics.com\/glp-1-pipeline-update-may-2025<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/primetherapeutics.com\/glp-1-pipeline-november-2024<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.primetherapeutics.com\/glp-1-pipeline-update-november-2024<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/www.beckershospitalreview.com\/glp-1s\/glp-1-drug-approvals-a-breakdown.html<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/acgng.org\/most-popular-glp-1-medications\/<\/span><\/b><\/a>\u00a0<\/span><\/p>\n

https:\/\/sanemd.com\/glp-1-medications\/glp-1-medications-list-benefits-uses-side-effects\/<\/span><\/b><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Curious about the science behind today\u2019s most talked-about diabetes and weight-management treatments? Our new, four-part blog series on GLP-1 Agonists will break down everything you need to know \u2014 from how these drugs work, to their real-world results, side effects, and what\u2019s coming next in the pipeline. GLP-1 stands for glucagon-like peptide-1. It\u2019s an incretin<\/p>\n","protected":false},"author":964,"featured_media":35571,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[603,605,487,489,513,515],"tags":[],"class_list":["post-35570","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-obesity-weight-loss","category-diabetes","category-drug-development","category-industry-news","category-health-and-wellness","category-health-guides","category-603","category-605","category-487","category-489","category-513","category-515","description-off"],"acf":[],"yoast_head":"\nGLP-1: Understanding Its Role in Diabetes Management - JoinAStudy.ca<\/title>\n<meta name=\"description\" content=\"Unlock the science behind GLP-1 and its effects on weight and diabetes management. 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