Are you Overweight and Looking to Lose Weight, While Struggling With Knee Osteoarthritis?
The main purpose of this study is to evaluate the safety and efficacy of a once-weekly, experimental medication for participants who have obesity or are overweight and have osteoarthritis (OA) of the knee. The study will last about 77 weeks.
Would you like to take part?
As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular follow-up of your health to monitor the effectiveness of the care you’ll receive. The results of this research will be used to find out if the investigational medication being studied will be of benefit to others struggling with obesity, and whether it will be made widely available to all Canadians trying to manage obesity. Study volunteers are an important part of moving medical care forward.
You may qualify to participate in this study if you:
- Have a body mass index (BMI) ≥27 kilogram/kg/m² at screening.
- Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight.
- Have index knee pain for >12 weeks prior to screening, and presence of index knee pain for >15 days over the previous month.
- Have knee X-ray with moderate radiographic changes (Kellgren-Lawrence Grade 2 or 3) per central reading at screening.
- Currently meet American College of Rheumatology (ACR) Criteria (clinical and radiological) for OA.
You may not qualify to participate if you:
- Have had steroid joint injections within 90 days of screening.
- Have had other joint injections and procedures within 6 months of screening.
- Have joint disease other than osteoarthritis.
- Have a self-reported or documented change in body weight >5 kg (11 pounds) within 90 days prior to screening.
- Have been taking weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
- Have a prior or planned surgical treatment for obesity.
- Have diabetes mellitus
There are other eligibility requirements that the study doctor will review. Only the study doctor can finally determine whether you are eligible to participate in the study or not.