Study for Participants With Osteoarthritis Knee Pain and Obesity
About this study
Are you Struggling With Obesity and Knee Pain Caused by Osteoarthritis?
The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.
Would you like to take part?
As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular follow-up of your health to monitor the effectiveness of the care you’ll receive. The results of this research will be used to find out if the investigational medication being studied will be of benefit to others struggling with obesity and osteoarthritis related pain, and whether it will be made widely available to all Canadians trying to manage these conditions. Study volunteers are an important part of moving medical care forward.
Who may qualify
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
- Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Have osteoarthritis of the knee and at least one of the following conditions:
- Be over 50 years old
- Have morning knee stiffness that lasts about 30 minutes
- Have a crackling or grinding sound or feeling in the knee
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have an active knee infection
- Have had within 90 days prior to screening:
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
- Have taken medications or alternative remedies intended for weight loss within 90 days of screening
What participation may involve
- Regular visits with the study team at no cost
- Study assessments and health monitoring throughout
- Check-ins between visits
- Informed consent before anything begins — questions welcome
What participants may receive
- Study-related care from a physician-led team
- Study assessments at no cost
- Reimbursement for reasonable travel, where applicable
Where this study is enrolling
Learn more
Osteoarthritis
Osteoarthritis is the most common form of arthritis in Canada. It affects the whole joint: the cartilage that cushions the ends of the bones, the bone underneath, and…
Read about this condition →Weight Conditions (Overweight, Obesity)
Obesity is a long-term medical condition in which extra body fat builds up to a point where it can affect health. Canadian clinical guidelines describe it as a…
Read about this condition →General Health
General health is the part of clinical research that is not built around a single diagnosis: prevention, vaccines, healthy ageing, weight and smoking, and studies that need volunteers…
Read about this condition →
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