A Research Study for Participants with Graves' Disease

Grave's disease

Do you suffer from Graves’ Disease?

This clinical research study is evaluating an experimental treatment for Graves’ Disease.

The main purpose of this study is to look at how the investigational medication affects thyroid function in adults with Graves’ Disease (GD). The study will also check whether this medication is safe and well tolerated. It will look at how it is distributed and eliminated in the body, how it changes antibody levels, and how the immune system responds to it.

The total study duration for participants ranges from 63 to 135 weeks, depending on the response to treatment.

Would you like to take part?

As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular follow-up of your health to monitor the effectiveness of the care you’ll receive. The results of this research will be used to find out if the investigational medication being studied will be of benefit to others with Graves’ Disease, and whether it will be made widely available to all Canadians. Study volunteers are an important part of moving medical care forward.

You may qualify to participate in this study if you:

Are at least 18 years of age when signing the Informed Consent document.
Have a documented diagnosis of Graves’ disease with TRAb (anti-thyrotropin receptor antibody) levels >=ULN (upper limit of normal) at screening
Have active hyperthyroidism due to Graves’ disease with TSH (thyroid-stimulating hormone) <0.1 mIU/L at screening
Have been treated with MMI (methimazole) or CBZ (carbimazole) for at least 3 months before screening

You may not qualify to participate if you:

Have a history of hyperthyroidism not caused by Graves’ disease (eg, toxic adenoma or toxic multinodular goiter)
Have a history of RAI (radioactive iodine) therapy or received a total thyroidectomy
Have taken a T3- or T4-containing medication or supplement (eg, levothyroxine, liothyronine, desiccated thyroid preparations, or thyroid-support supplements) <6 weeks before screening
Have any complication of hyperthyroidism or underlying medical condition that would put you at undue risk. This includes arrhythmia or tachyarrhythmia related to Graves’ disease, such as atrial fibrillation or atrial flutter not sufficiently controlled with medications.
Have Graves’ orbitopathy/Thyroid Eye Disease (GO/TED) requiring systemic therapy (eg, corticosteroids), orbital injections, orbital surgery, or orbital radiation, or expected immediate surgical intervention and/or planned corrective surgery/irradiation or medical therapy during the study

There are other eligibility requirements that the study doctor will review. Only the study doctor can finally determine whether you are eligible to participate in the study or not.

Click the JOIN button if you think you might be eligible for this study.

All information about you will be kept confidential and will never be used or disclosed for any purpose not described in our Privacy Policy.

After providing us with your contact information, a research professional will get in touch to further assess your eligibility, answer any questions you have about the study, and determine if you qualify for participation.

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Click the JOIN button if you think you might be eligible for this study.

Please complete the form below with your contact information.

Terms and Conditions

All information about you will be kept confidential and will never be used or disclosed for any purpose not described in our Privacy Policy.

After providing us with your contact information, a research professional will get in touch to further assess your eligibility, answer any questions you have about the study, and determine if you qualify for participation.

A Research Study for Participants with Graves’ Disease

Click the JOIN button if you think you might be eligible for this study.

All information about you will be kept confidential and will never be used or disclosed for any purpose not described in our Privacy Policy.

After providing us with your contact information, a research professional will get in touch to further assess your eligibility, answer any questions you have about the study, and determine if you qualify for participation.